Similar to the way in which integrated circuits (ICs) revolutionized electronics, the advent of integrated microfluidic circuitry could significantly impact both chemical and biological fields. Here we utilize fluidic techniques routed in mechanical engineering to develop next-generation microfluidic components and systems that are capable of autonomous “on-chip” functionalities.
Continuous Flow Particulate-Based Microfluidic Reactors
The ability to perform “multi-stage” fluidic mixing operations with suspended particles, such as living cells and micro/nanobeads, is a critical requirement for diverse chemical and biological applications. In our lab, we combine hydrodynamic railing and arraying techniques to passively execute multi-step particulate-based fluidic reaction processes, while enabling optical detection during each fluidic mixing stage.
- Ryan D. Sochol, Daniel Corbett, Sarah Hesse, William E.R. Krieger, Ki Tae Wolf, Minkyu Kim, Kosuke Iwai, Song Li, Luke P. Lee and Liwei Lin, Dual-Mode Hydrodynamic Railing and Arraying of Microparticles for Multi-Stage Signal Detection in Continuous Flow Biochemical Microprocessors, Lab on a Chip, 2014. Advance Article available online @ DOI:10.1039/C4LC00012A
- Ryan D. Sochol, Song Li, Luke P. Lee and Liwei Lin, Continuous Flow Multi-Stage Microfluidic Reactors via Hydrodynamic Microparticle Railing, Lab on a Chip, Vol. 12, pp.4168-4177, 2012.
- (ORAL) OUTSTANDING PAPER AWARD Ryan D. Sochol, Ryan Ruelos, Valerie Chang, Megan Dueck, Luke P. Lee, and Liwei Lin, Continuous Flow Layer-by-Layer Microbead Functionalization via a Micropost Array Railing System, Proceedings of the 16th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2011), Beijing, China, June 5-9, 2011. View Oral Presentation on YouTube